---
name: sample-correlation-analysis-942729908791
description: Use when performing correlation analysis between two variables including Pearson and Spearman correlation methods. Supports command-line parameter input, automatic data format detection, parameter validation, result directory creation, and CSV or TXT format result export.
license: MIT
author: AIPOCH
---
> **Source**: [https://github.com/aipoch/medical-research-skills](https://github.com/aipoch/medical-research-skills)

# Correlation Analysis

Use this skill to run correlation analysis on two variables from a tabular data file.

## Use This Skill When

- You need Pearson or Spearman correlation between two variables stored either as columns or as first-column row labels.
- You need a command-line workflow with parameter validation.
- You need standardized output files in CSV or TXT format.

## Primary Command

```bash
Rscript scripts/main.R \
  --data_file <input_file> \
  --method <pearson|spearman> \
  --x_var <variable_name> \
  --y_var <variable_name> \
  --output_dir <output_dir>
```

## Prerequisites

- Rscript is available in the shell.
- Required R packages: `optparse`, `data.table`.
- Install missing packages with `Rscript -e 'install.packages(c("optparse", "data.table"), repos="https://cloud.r-project.org")'`.

## Core Arguments

| Argument | Required | Description |
|----------|----------|-------------|
| `--data_file` | Yes | Input data file in CSV, TXT, or TSV format |
| `--method` | No | Correlation method: `pearson` or `spearman`. Default `pearson` |
| `--x_var` | No | First variable name. It can match a column name or a first-column row label. Default `variable1` |
| `--y_var` | No | Second variable name. It can match a column name or a first-column row label. Default `variable2` |
| `--output_dir` | No | Output directory, default `./Correlation_Results` |
| `--alternative` | No | `two.sided`, `less`, or `greater`. Default `two.sided` |
| `--conf_level` | No | Confidence level between 0 and 1, default `0.95` |
| `--output_format` | No | `csv` or `txt`, default `csv` |
| `--output_prefix` | No | Output filename prefix, default `correlation` |

## Input Requirements

- The input file must contain both target variables.
- Both variables must contain numeric values.
- If the first column stores variable names and the remaining columns are samples, the script automatically reads variables by row label.
- Rows with missing values in either variable are excluded.
- At least 3 complete observation pairs are needed.

Example input:

```csv
variable1,variable2
10.2,8.5
11.5,9.2
9.8,7.9
```

## Minimal Workflow

1. Confirm the input file exists and variable names are correct.
2. Run `scripts/main.R` with the requested method and variable names.
3. Check the output directory for result files under `table/`.

If you omit `--data_file`, the script exits with `SKILL_MISSING_INPUT`.

## Outputs

Expected output structure:

```text
<output_dir>/
├── table/
├── figure/
└── data/
```

Primary result file:

- `table/<output_prefix>_<method>.csv`
- `table/<output_prefix>_<method>.txt`

Result fields include:

- `method`
- `correlation`
- `statistic`
- `p_value`
- `conf_low`
- `conf_high`
- `sample_size`
- `x_variable`
- `y_variable`
- `variable_orientation`

## Choose the Method

- Use `pearson` for linear relationships between continuous variables.
- Use `spearman` for monotonic relationships, non-normal data, or outlier-prone data.

## Read These Files When Needed

| Need | File |
|------|------|
| Statistical details and assumptions | `references/algorithm.md` |
| More CLI examples | `references/cli-guide.md` |
| Error diagnosis | `references/troubleshooting.md` |
| Main execution entry point | `scripts/main.R` |
| Sample test data | `tests/data/` |

## Quick Examples

Pearson:

```bash
Rscript scripts/main.R \
  --data_file tests/data/sample_correlation_1.csv \
  --method pearson \
  --x_var variable1 \
  --y_var variable2 \
  --output_dir tests/output_pearson
```

Spearman:

```bash
Rscript scripts/main.R \
  --data_file tests/data/sample_correlation_3.csv \
  --method spearman \
  --x_var "Activated CD8 T cell" \
  --y_var "Central memory CD8 T cell" \
  --output_dir tests/output_spearman
```

## Validation

```bash
Rscript scripts/main.R --help
```

```bash
Rscript scripts/main.R \
  --data_file tests/data/sample_correlation_1.csv \
  --method pearson \
  --x_var variable1 \
  --y_var variable2 \
  --output_dir tests/validation_output
```

After running analysis, verify that `tests/validation_output/table/correlation_pearson.csv` exists.

## Common Errors

- `SKILL_FILE_NOT_FOUND`: Input file path is wrong or inaccessible.
- `SKILL_MISSING_COLUMNS`: One or both requested variables are missing.
- `SKILL_INVALID_DATA`: Input data is malformed or unsuitable for analysis.
- `SKILL_INVALID_PARAMETER`: An argument value is invalid.
- `SKILL_INSUFFICIENT_DATA`: Too few complete observations remain after filtering.
- `SKILL_DEPENDENCY_MISSING`: A required R package such as `optparse` or `data.table` is unavailable.

If the issue is not obvious, read `references/troubleshooting.md`.


---
Source attribution: aipoch
Original project: https://github.com/aipoch/medical-research-skills
License: MIT
License information: https://opensource.org/license/mit
Original upstream instructions; downloaded from Mega AI Hub.

## Upstream license notice

MIT License

Copyright (c) 2026 Gabriel Moreira

Permission is hereby granted, free of charge, to any person obtaining a copy
of this software and associated documentation files (the "Software"), to deal
in the Software without restriction, including without limitation the rights
to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
copies of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all
copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
SOFTWARE.



# Mega AI Hub resource metadata

Creator / publisher: aipoch
Original project: https://github.com/aipoch/medical-research-skills
Attribution basis: Upstream repository explicitly recorded in package mirror path

Fields of work: Data & Analytics
Roles: Data Analyst, Data Scientist, Market Research Analyst
Specialties: API
Tools: Rscript
Country applicability: Country not specified
Classification basis: Source catalog labels
Instruction SHA-256: 5e0af4e59e4989d1f8eb6096551200c81207bfc629ece44b91705b793fca3500
