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Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outco...
Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR ...
End-to-end post-GWAS causal inference pipeline orchestrating heritability partitioning, genetic correlation, Mendelian randomization with CHP-aware sensitivity (CAUSE / LHC-MR), colocalization, fine-mapping with SuSiE / FOCUS, mediation, TWAS triangulation, cis-pQTL drug-target MR, effector-gene ...
Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein...
Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, ca...
Agent skill for Data Scientist, Business Intelligence Analyst, Researcher, published by Rudson-Oliveira. Project details and file access are provided by the publisher.
Agent skill for Data Scientist, Researcher, Business Intelligence Analyst, published by Rudson-Oliveira. Project details and file access are provided by the publisher.
Agent skill for Data Scientist, Researcher, Business Intelligence Analyst, published by FridrichMethod. Project details and file access are provided by the publisher.
Agent skill for Data Scientist, Researcher, Business Intelligence Analyst, published by FridrichMethod. Project details and file access are provided by the publisher.
Agent skill for Researcher, Data Scientist, Business Intelligence Analyst, published by BioTender-max. Project details and file access are provided by the publisher.
Agent skill for Researcher, Data Scientist, Business Intelligence Analyst, published by BioTender-max. Project details and file access are provided by the publisher.
Agent skill for Researcher, Data Scientist, Business Intelligence Analyst, published by BioTender-max. Project details and file access are provided by the publisher.
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